Methotrexate-related lymphoproliferative disorder with extensive vascular involvement in a patient with rheumatoid arthritis Shimura C et al. - The authors describe the development of a cutaneous lymphoproliferative disorder in a patient with rheumatoid arthritis who was treated with methotrexate. Skin manifestations were characterized by thrombophlebitis-like lesions and ulcerated nodules. Histologic examination revealed large polymorphic atypical cells including Reed-Sternberg–like cells expressing CD20 and CD30 in the dermis and subcutaneous tissues. [more...]
