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Kermorvant–Duchemin E et al. – This review summarizes the most recent aspects of the research on OIR conducted in the laboratory and others, with a particular focus on the role of new mediators of nitro–oxidative stress, the trans–arachidonic acids, in microvascular degeneration, and on a novel pathway of metabolic signaling where hypoxia–driven succinate, via receptor GPR91, governs normal and pathological retinal angiogenesis.

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