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Understanding ischemic retinopathies: emerging concepts from oxygen-induced retinopathy
Documenta Ophthalmologica, 11/03/09
Kermorvant–Duchemin E et al. – This review summarizes the most recent aspects of the research on OIR conducted in the laboratory and others, with a particular focus on the role of new mediators of nitro–oxidative stress, the trans–arachidonic acids, in microvascular degeneration, and on a novel pathway of metabolic signaling where hypoxia–driven succinate, via receptor GPR91, governs normal and pathological retinal angiogenesis.
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