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Ocular Surface Distribution and Pharmacokinetics of a Novel Ophthalmic 1% Azithromycin Formulation
Journal of Ocular Pharmacology and Therapeutics, 11/09/09

Akpek EK et al. – Sustained and high concentrations were encountered with 7–day approved administration of 1% azithromycin formulation within all ocular surface tissues, particularly the lids. Many ocular surface disorders involving the tear film, eyelids, and adnexal structures are associated with chronic, low–grade bacterial infection and may potentially lead to decreased vision secondary to corneal scarring. Various topical antibiotic and steroid combinations with or without oral tetracyclines are commonly used with variable clinical response and known potential side effects.

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