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Analysis of chromosomal aberration (1, 3, and 8) and association of microRNAs in uveal melanoma
Molecular Vision, 10/26/09

Radhakrishnan A et al. – This technique can be applied to routine pathology using archival specimens to identify patients with monosomy 3. The authors were able to perform CISH in all the cases except the heavily pigmented tumors, where dots were observed but were not assessed. Initial studies on microRNA have revealed their role as oncomirs in both metastasizing and non–metastasizing melanomas. Further studies may provide insights into their role in tumor progression and facilitate metastatic phenotype analysis.

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