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Nerve growth factor modulates toll-like receptor (TLR) 4 and 9 expression in cultured primary VKC conjunctival epithelial cells
Molecular Vision, 10/21/09
Micera A et al. – These data indicate that NGF is able to induce TLR4/TLR9 overexpression in VKC–ECs. These cells exhibited poor IL–4, IL–12 p40, and IFN– Gamma responses to NGF, while a significant IL–10 decreased secretion was detected. The different NGF–induced TLR response between VKC and healthy–control conjunctival ECs as well as the different cytokine response might reflect a different pattern of cell activation according to the state of VKC.
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