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Retinal ischemia-induced apoptosis is associated with alteration in Bax and Bcl-xL expression rather than modifications in Bak and Bcl-2
Molecular Vision, 10/20/09
Produit–Zengaffinen N et al. – This study revealed that Bcl–2–related family members were differently regulated in the early and late phases after an ischemic insult. The authors showed that the Bax:Bcl–2 and Bax:Bcl–xL balances were not affected in the initial phases, but the Bax:Bcl–xL ratio shifted toward apoptosis during the late phase of recovery. This shift was reinforced by caspase–3 upregulation.
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