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Growth Factor Regulation of Corneal Keratocyte Differentiation and Migration in Compressed Collagen Matrices
Investigative Ophthalmology and Visual Science, 10/15/09
Kim A et al. – Corneal keratocytes are able to differentiate normally and respond to growth factors within compressed collagen matrices, which provide a high stiffness 3–D environment, similar to native stromal tissue. In addition, nesting these matrices provides a unique platform for investigating the mechanics of keratocyte migration following exposure to specific wound healing cytokines.
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