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See Latest ArticlesAntiangiogenic therapy with anti-vascular endothelial growth factor modalities for diabetic macular oedema
Cochrane Reviews, 10/19/09
Parravano M et al. – The authors included four studies in this review. The authors found two small studies, comparing pegaptanib with sham or bevacizumab with sham in patients with clinically significant macular oedema (CSMO), that showed results in favour of antiangiogenic therapy but could not reliably demonstrate a benefit. An additional small study compared bevacizumab to photocoagulation in eyes with untreated CSMO and its results also favoured antiangiogenic therapy, but not reliably so. Other comparisons were between bevacizumab and triamcinolone, or between bevacizumab alone and bevacizumab plus triamcinolone in three studies which did not show a difference. Three out of the four studies were at risk of bias. Antiangiogenic treatment was well tolerated in these studies, but since all studies were short–term, the authors were unable to investigate long–term effects as well as risks. Although several studies are ongoing, there is not sufficient high quality evidence on the use of anti–VEGF drugs for the treatment of DMO yet.
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