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See Latest ArticlesPlatelet-derived growth factor-BB: a stimulus for cytokine production by orbital fibroblasts in Graves' Ophthalmopathy
Investigative Ophthalmology and Visual Science, 10/15/09
Steensel LV et al. – PDGF–BB is a potent inducer of pro–inflammatory cytokines via the NF–kappaB pathway in orbital fibroblasts whereas cytokine production by fibroblasts from other anatomical locations showed a moderate response. These data suggest a possible role for PDGF–BB in regulating orbital inflammation in GO and identify the PDGF–signaling cascade as therapeutic target in GO.
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