Ophthal Medical News about Conjunctivitis, Bacterial

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Besifloxacin, a new ophthalmic fluoroquinolone for the treatment of bacterial conjunctivitis
Expert Opinion in Pharmacotherapy, 09/14/09

Bertino JS et al. – The low minimum inhibitory concentrations and high attainment of pharmacodynamic targets with besifloxacin may contribute to a lower risk for the emergence of bacterial resistance, although further studies are needed. These data indicate that besifloxacin ophthalmic suspension 0.6% is an important new option for the treatment of bacterial conjunctivitis.

Exclusive Author Commentary
Joseph S Bertino, 09/24/09

This article discusses a new opthalmic antibiotic besifloxacin and its use in bacterial conjunctivitis. Antibiotic resistance continues to be a major problem in treatment. Newer agents such as besifloxacin may be useful in drug resistant bacterial infections. Besifloxacin optimized the pharmacodynamic ratios needed to attain good bacterial cure, and to potentially prevent the development of resistance. In clinical trials, besifloxacin was used for a 5 day treatment, however, the FDA requested a 7 day treatment in the label, no reason given.

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