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See Latest ArticlesSilencing of the CHM gene alters phagocytic and secretory pathways in the retinal pigment epithelium
Investigative Ophthalmology and Visual Science, 09/17/09
Gordiyenko NV et al. – Lack of REP–1 protein expression in hfRPE cells leads to (1) reduced degradation of POS most likely due to the inhibition of phagosome–lysosome fusion events, and (2) increased constitutive secretion of MCP–1 and IL–8. These observations may explain the accumulation of unprocessed outer segments within the phagolysosomes of RPE cells and the presence of inflammatory cells in the choroid of CHM patients.
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Today in Retina...keeping you current
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Pre-Treatment with Intravitreal Triamcinolone Prior to Laser for Diabetic Macular Edema: 6-Month Results of a Randomised, Placebo-Controlled Trial
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