Ophthal Medical News about Ocular ischemic syndrome

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Acute Vision Loss after Intravitreal Injection of Bevacizumab (Avastin) Associated with Ocular Ischemic Syndrome
Ophthalmologica, 08/26/09

Huang ZL et al. – Patients receiving intravitreal injections of bevacizumab should be evaluated for potential systemic risk factors such as carotid insufficiency, coagulopathy and poorly controlled diabetes mellitus. Acute ocular ischemic change may be associated with intravitreal injection of bevacizumab in patients with vascular compromised diabetic retinopathy and/or underlying stenosis of the carotid artery.

Exclusive Author Commentary
Rong-Kung Tsai, 08/31/09

Intravitreal injections of bevacizumab have been widely used to treat retinal neovascularization. However, in certain patients already with severe ocular ischemia, VEGF is necessary to manitain the tissue perfusion in the retinas, and anti-VEGF treatment in such a case may result in damage of retinal microcirculation. This is the lesson we learned from our patient.

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A Phase I Study of Intravitreal Vascular Endothelial Growth...

Ocular ischemic syndrome: recent trends in medical management
Current Opinion in Ophthalmology, 10/27/09 Relevance Score: 79%

Therapeutic Angiogenesis by Controlled-Release Fibroblast Growth Factor in a Patient With Churg-Strauss Syndrome Complicated by an Intractable Ischemic Leg Ulcer
The American Journal of the Medical Sciences, 10/20/09 Relevance Score: 67%

Goldenhar syndrome with unusual association of pre-axial polydactyly
European Journal of Ophthalmology, 11/13/09 Relevance Score: 66%

Profound retinal ischaemia after ranibizumab administration in an eye with ocular ischaemic syndrome
Acta Ophthalmologica, 10/14/09 Relevance Score: 66%

49,XXXXY Syndrome with Autoimmune Diabetes and Ocular Manifestations
Medical Principles and Practice, 10/05/09 Relevance Score: 66%