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Imatinib induces apoptosis by inhibiting PDGF- but not insulin-induced PI 3-kinase/Akt survival signaling in RGC-5 retinal ganglion cells
Molecular Vision, 08/19/09
Biswas SK et al. – These data indicate that disruption of PDGF receptor signaling compromises the pro–survival effect of insulin–induced IRS–dependent PI 3–kinase/Akt signaling in RGCs, and that the maintenance of PDGF–induced PI 3–kinase/Akt signaling is critical for the survival of retinal neuronal cells.
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Today in Basic Science/Genetics...keeping you current
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NADPH oxidase expression and production of superoxide by human corneal stromal cells
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