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Effects of Benzo(e)Pyrene on the Retinal Neurosensory Cells and Human Microvascular Endothelial Cells In Vitro
Current Eye Research, 08/21/09
Patil AJ et al. – In R28 cells, 200 and 100 micro M of B(e)P causes activation of caspase–3/7, –8 and –12 pathways, leading to apoptotic cell death, but, at higher concentrations, there is non–apoptotic cell death, which could be due to necrosis. In contrast, the HMVEC cell death is through non–caspase–dependent necrosis pathway.
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