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In vivo characterization of doxycycline effects on tear metalloproteinases in patients with chronic blepharitis
European Journal of Ophthalmology, 08/14/09

Iovieno A et al. – This study suggests that 4–week treatment with doxycycline significantly improved symptoms and signs in patients with chronic blepharitis in association with a decrease in MMP–9 activity. Upregulation of TIMP–1 is proposed as a possible mechanism of MMP–9 inactivation.

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