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Benzalkonium Chloride Enhances Antibacterial Activity of Gatifloxacin and Reduces its Propensity to Select for Fluoroquinolone-Resistant Strains
Journal of Ocular Pharmacology and Therapeutics, 08/04/09

Hesje CK et al. – BAK substantially lowered the MIC and MPC of gatifloxacin and moxifloxacin against Gram–positive staphylococci compared to gatifloxacin alone, moxifloxacin alone, and/or levofloxacin. These findings suggest that the presence of BAK in the ophthalmic formulation of gatifloxacin (Zymar) may serve to enhance the potency of gatifloxacin and decrease its propensity to select for fluoroquinolone–resistant S. aureus strains.

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Chronic Obstructive Pulmonary Disease: Role of Bacteria and Updated Guide to Antibacterial Selection in the Older Patient
Drugs & Aging, 11/25/09 Relevance Score: 91%%

Bacterial tyrosine kinases: novel targets for antibacterial therapy
Trends in Microbiology, 11/04/09 Relevance Score: 84%%

MDP-NOD2 stimulation induces HNP-1 secretion, which contributes to NOD2 antibacterial function
Inflammatory Bowel Disease, 10/26/09 Relevance Score: 84%%

Antibacterial-Resistant Pseudomonas aeruginosa: Clinical Impact and Complex Regulation of Chromosomally Encoded Resistance Mechanisms
Clinical Microbiology Reviews, 10/14/09 Relevance Score: 83%%

Impairment of Interferon-gamma Signaling in Human Neutrophils Infected with Anaplasma phagocytophilum
Infection and Immunity, 10/30/09 Relevance Score: 80%%