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Efficacy of topical cyclosporine A in the treatment of severe trachomatous dry eye
Clinical and Experimental Ophthalmology, 07/31/09
Guzey M et al. – Topical CsA was effective in the treatment of severe trachomatous dry eye, yielding improvements in both objective and subjective measurements with a safety profile.
Dr Mustafa Guzey, Assoc. Prof. of Ophthalmology, 07/31/09
| Trachomatous conjunctival cicatrization destroys basic secretory system and obliterates lacrimal gland excretory ductules, resulting in a dry eye There is no current therapeutic treatment for severe trachomatous dry eye disease. In preliminary studies, treatment with topical CsA improved the signs and the symptoms of dry eye syndrome. An increase in goblet cell counts was reported in association with clinical improvement. Reduced numbers of activated T lymphocytes in conjunctiva and a decrease in IL’s in conjunctival epithelium were also observed. CsA significantly improved corneal staining, Schirmer scores and significantly increased conjunctival goblet cell density. Topical CsA treatment may be effective for the improvements of ocular surface integrity in patients with trachomatous dry eye. |
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