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See Latest ArticlesBves Overexpression in Trabecular Meshwork Cells Inhibits RhoA Signaling
Investigative Ophthalmology and Visual Science, 07/27/09
Russ PK et al. – Increased Bves in TM cells leads to increased TJ formation with decreased RhoA activation and decreased MLC–p. This is the first report of a regulatory pathway upstream of RhoA in TM cells. In TM tissue, RhoA has been implicated in outflow regulation, and thus Bves may be a key regulatory molecule in aqueous outflow.
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