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Seth RK et al. – There was no statistically significant change in the vertical C/D of optic nerves in patients receiving multiple intravitreal injections of anti–VEGF agents, regardless of whether they received fewer or more than five total injections. This suggests that the short–term intraocular pressure rise and frequent intraocular pressure fluctuation, as well as the anti–VEGF properties of these drugs, do not adversely change the optic nerve C/D. Additional prospective studies are warranted to confirm these conclusions.


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