Ophthal Medical News about uveal melanoma

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Episodic Src activation in uveal melanoma revealed by kinase activity profiling
British Journal of Cancer, 07/01/09

Maat W et al. - The authors identified Src as an important kinase and a potential target for treatment in primary UM. Metastasis cell lines seemed largely resistant to Src inhibition and indicate that in metastases treatment, a different approach may be required.

Exclusive Author Commentary
P A van der Velden, 07/02/09

Tumor development is often driven by overactive kinases and these tumor promoters turn out to be good targets for treatment. Using kinase assays we could distinguish cell lines based on Src kinase activity and this correlated with efficacy of Src kinase inhibitor treatment. Measuring kinase activity in tumor specimen will assist to select the optimal therapy from a whole range of kinase inhibitors that are currently on the market.

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A reappraisal of the significance of largest basal diameter of posterior uveal melanoma
Eye, 11/02/09 Relevance Score: 68%

Update on posterior uveal melanoma: treatment of the eye and emerging strategies in the prognosis and treatment of metastatic disease
Current Opinion in Ophthalmology, 10/27/09 Relevance Score: 67%

Surgical management of liver metastases from uveal melanoma: 16 years experience at the Institut Curie
European Journal of Surgical Oncology, 10/21/09 Relevance Score: 67%

Intravascular presence of tumor cells as prognostic parameter in uveal melanoma: a 35-year survey
Investigative Ophthalmology and Visual Science, 10/15/09 Relevance Score: 67%

Molecular Prognostic Testing and Individualized Patient Care in Uveal Melanoma
American Journal of Ophthalmology, 10/06/09 Relevance Score: 67%