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Carreras FJ et al. - The stability of intercellular junctions of the nerve-vitreous boundary is sensitive to altered concentrations of Ca2+. Since aqueous humor has half the Ca2+ concentration of plasma, any contact of aqueous humor with the optic nerve head can interfere with the ionic concentration of calcium in the extracellular spaces. This mechanism may contribute to age-related changes and some types of glaucoma.

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