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Stiebel-Kalish H et al. - Current evidence demonstrates the efficacy of intravenous corticosteroids in decreasing CAS in patients with moderate-to-severe GO. Intravenous pulse corticosteroids therapy has a small but statistically significant advantage oral therapy, and causes significantly less adverse events. Somatostatin analogs have marginal clinical efficacy. The efficacy of orbital radiotherapy as single therapy remains unclear, while the combination of radiotherapy with corticosteroids has better efficacy than either radiotherapy or oral costicosteroids alone.

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