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Phenotypic Characterization of Retinoblastoma for the Presence of Putative Cancer Stem-like Cell Markers by Flow Cytometry
Investigative Ophthalmology and Visual Science, 04/15/09
Balla MMS et al. - Retinoblastoma, on flow cytometric analysis, revealed two distinct subpopulations with variable expression of stem cell and retinal progenitor markers. In these populations, the FSClo/SSClo subpopulation appeared to be more primitive, since they expressed stem cell and retinal progenitor markers combined with a relatively lower percentage of differentiated markers. Moreover, the FSChi/SSClo subpopulation showed a higher percentage of differentiated markers.
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