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Long BBS et al. - New and former wearers at 2 weeks showed increased epithelial microcysts. New and former wearers at 2 weeks compared with adapted wearers at baseline had less frequent early removal during the day, burning or stinging, uncomfortable lenses, and photophobia while reporting more problems inserting and removing lenses. No adverse events were reported with lotrafilcon A CLs. Adapted CL wearers showed improved clinical signs, subjective symptoms, and comfort when changed to lotrafilcon A for DW. New or former wearers showed few significant changes from baseline in clinical signs and had symptoms similar to nonsilicone hydrogel wearers.

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