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Tolerance to Melanin-Associated Antigen in Autoimmune Uveitis Is Mediated by CD4+CD25+ T-Regulatory Cells
American Journal of Pathology, 10/24/08
Matta B et al. - Adoptive transfer of tolerance failed when lymph nodes cells were depleted of CD4+CD25+ T cells. In conclusion, T-cell nonresponsiveness because of active suppression mediated by T-regulatory cells facilitates the development of tolerance to MAA in EAAU.
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Today in Uveitis...keeping you current
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A new HLA extended haplotype containing the A 2910 allele is also associated with birdshot retinochoroidopathy and narrows susceptibility to the disease to the HLA molecule itself
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