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Inhibition of Chemokine Receptor Expression on Uveal Melanomas by CXCR4 siRNA Blocks Tumor Cell Invasion and Liver Metastasis of Uveal Melanoma Cells
Li H et al. - CXCR4 is a key chemokine receptor that may account for the organ-specific homing of human uveal melanomas to the liver, which contains significant quantities of CXCL2, the only known ligand for CXCR4. CXCR4 is a potential therapeutic target for preventing the initial establishment of liver metastases, but has limited application for use in advanced liver tumors. [more...]

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