Regional Differences in Store Operated Ca2+ Entry in the Epithelium of the Intact Human Lens
Rhodes JD et al. - Greater Ca2+ store capacity and Ca2+-influx in E compared to CA reflect underlying differences in proliferation and differentiation between the regions. The relatively small resting Ca2+-influx in CA epithelium suggests that store operated Ca2+-entry (SOCE) is the main route of Ca2+-influx in these cells. Greater resting influx and SOCE in E cells suggests that these are a major route for Ca2+-influx into the lens. Increased expression of Orai1 and STIM1 in E could account for the differences in Ca2+ entry. [more...]
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