Timing of Corticosteroid Therapy is Critical to Prevent Retinal Ganglion Cell Loss in Experimental Optic Neuritis
Investigative Ophthalmology and Visual Science, 11/20/2009
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Shindler K et al. – Corticosteroids can suppress optic neuritis and prevent RGC loss if treatment is initiated prior to optic nerve inflammation onset. Treatment is less effective after inflammation ... recurrent optic neuritis and RGC damage.
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Optic neuritis - More than a loss of vision
Australian Family Physician, 10/05/2009
Chu ER et al. – This article provides information on the signs and symptoms of optic neuritis and discusses appropriate referral, investigations and management. - Demyelinating optic neuritis may be related to MS.
- Diagnosis is ... visual acuity, decreased colour vision, presence of RAPD, decreased subjective brightness and visual field abnormality. Appearance of the optic nerve head can either be swollen (papillitis) or normal.
- The characteristic white matter lesion on MRI brain is the most important predictor in ... acute episode of ON with IV methylprednisone followed by oral prednisolone hastens the rate of vision recovery.
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The effect of interferon beta-1a on optic neuritis relapse in patients with multiple sclerosis
Graefe's Archive for Clinical and Experimental Ophthalmology, 10/12/2009
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Chen YM et al. – The use of interferon beta–1a 44 micro g via subcutaneous injection three times weekly did not increase the ON attacks in MS patients receiving this treatment. In addition ... the use of interferon beta–1a on these patients.
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Multiple sclerosis. Part I: Neuro-ophthalmic manifestations
Current Opinion in Ophthalmology, 10/29/2009
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Pula JH et al. – Multiple sclerosis results in various ophthalmic abnormalities. Optic neuritis is the most widely studied visual disturbance in MS, but other unusual visual manifestations such as Charles Bonnet syndrome or the Pulfrich ... loss, OCT is being used to evaluate neuroprotective treatments. The efferent visual system, in particular the medial longitudinal fasciculus pathway, may be a way to measure body temperature–induced changes in MS.
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Importance of background rates of disease in assessment of vaccine safety during mass immunisation with pandemic H1N1 influenza vaccines
The Lancet - Early Online Publication, 11/02/2009
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Black S et al. – In female vaccinees in the USA, 86·3 cases of optic neuritis per 10 million population would be expected within 6 weeks of vaccination. 397 per 1 million vaccinated pregnant women would be predicted to
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Magnetic Resonance Imaging in Acute Optic Neuritis in Singapore
Annals, Academy of Medicine, Singapore, 10/13/2009
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Lim SA et al. – The study revealed a lower percentage of grade II–IV brain MRI abnormalities as well as less lesion load in idiopathic ON compared to the ONTT. This may be related to the lower prevalence of MS in the ... lower than for retrobulbar disease. MRI in ON has an essential role in characterising the disease, evaluating for associated brain lesions, and assessing prognosis in retrobulbar disease but may be less useful in anterior disease.
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Optical diagnosis of small colorectal polyps at routine colonoscopy (Detect InSpect ChAracterise Resect and Discard; DISCARD trial): A prospective cohort study
The Lancet Oncology - Online First, 11/12/2009
Ignjatovic A et al. – For polyps less than 10 mm in size, in-vivo optical diagnosis seems to be an acceptable strategy to assess polyp ... experience predicted polyp histology using optical diagnosis with high-definition white light, followed by narrow-band imaging without magnification and chromoendoscopy, as required Primary outcome accuracy of polyp characterisation using optical diagnosis compared with histopathology ... optical diagnosis to predict the next surveillance interval also assessed and compared with surveillance intervals predicted by current guidelines using histopathologyResults- 363 polyps smaller than 10 mm detected in 130 patients, of which 278 polyps had both optical and ... li>
- Optical diagnosis accurately diagnosed 186 of 198 adenomas (sensitivity 0·94; 95% CI 0·90—0·97) and 55 of 62 hyperplastic polyps (specificity 0·89; 0·78—0·95), overall accuracy of 241 of 260 (0·93, 0·89—0·96) for polyp characterisation
- Using optical diagnosis alone, 82 of 130
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Influence of optic quality on contrast sensitivity and visual acuity in eyes with a rigid or flexible phakic intraocular lens
Journal of Cataract & Refractive Surgery, 11/12/2009
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Peris–Martínez C et al. – Optic quality, measured by modulation transfer function and evaluated by average modulation, was approximately 13% better with the ... the flexible pIOL. However, the difference was not enough to affect visual quality. At 1 year, the 2 groups had similar CDVA and contrast sensitivity function values, indicating that other optical or neural factors compensate for differences in optic quality.
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Prediction of Functional Loss in Glaucoma From Progressive Optic Disc Damage
Archives of Ophthalmology, 10/22/2009
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Medeiros FA et al. – Presence of progressive optic disc damage on stereophotographs was a highly predictive factor for future development of functional loss in glaucoma. These findings suggest the importance of careful monitoring of the optic disc appearance and ... role for longitudinal assessment of the optic disc as an end point in clinical trials and as a reference for evaluation of diagnostic tests in glaucoma.
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Functional microperimetry and SD-OCT confirm consecutive retinal atrophy from optic nerve pit
Clinical Ophthalmology, 11/11/2009
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Brar VS et al. – Recently, spectral–domain optical coherence tomography has been reported to demonstrate a communication between the optic nerve sheath and the subretinal space. Vitreous cavity is proposed as an ... subretinal space. The authors imaged a patient with optic nerve pit with Spectralis OCT and report the findings seen including the presence of an area of peripapapillary retinal atrophy, due to the spontaneous resolution of associated long–standing retinal detachment.
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