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Diffuse and heterogeneous T2-hyperintense lesions in the splenium are characteristic of neuromyelitis optica
Multiple Sclerosis Journal, 07/27/2012
Clinical Article
Makino T et al. – Diffuse and heterogeneous T2 hyperintense splenial lesions were characteristic of neuromyelitis optica (NMO). These findings could help distinguish NMO from multiple sclerosis (MS) on MRI.
Methods- Japanese patients with NMO (n=28) or MS (n=22) were assessed.
- The distributions and appearances of callosal lesions were evaluated on a brain mid-sagittal T2-weighted image (T2WI) or a fluid-attenuated inversion recovery image with a 1.5T MRI scanner.
- Logistic regression analysis identified which characteristics of the callosal lesions were useful for discriminating NMO from MS.
- Callosal lesions were present in 79% of NMO and 82% of MS patients.
- Callosal abnormalities of NMO, including splenial lesions (57% in NMO versus 27% in MS, odds ratio (OR)=4.23, p=0.04), diffusely spreading lesions from the lower to upper edges of the corpus callosum (71% versus 23%, OR=7.18, p=0.0024), and heterogeneous T2 hyperintense lesions (71% versus 9%, OR=44.3, p=0.0006), were feasible for discriminating NMO from MS.
