Treatment of Conjunctival and Corneal Epithelial Neoplasia with Retinoic Acid and Topical Interferon Alfa-2b: Long-term Follow-up
Krilis M et al. – In this group of patients observed with corneal intraepithelial neoplasia (CIN) lesions, combination treatment of topical retinoic acid and interferon alfa–2b was effective in treating lesions with minimal self–limited side effects with faster and greater resolution and a longer tumor–free period compared with studies using interferon alfa–2b alone. The authors hypothesize that topical all–trans retinoic acid and interferon alfa–2b may act synergistically. The authors believe that combination treatment of interferon alfa–2b and retinoic acid may offer a superior alternative to interferon alfa–2b alone in treating CIN.