A Double-Blind, Placebo-Controlled, Crossover Trial Comparing the Effects of Amiloride and Hydrochlorothiazide on Glucose Tolerance in Patients With Essential Hypertension Full Text
Hypertension,  Clinical Article

Stears AJ et al. – No impairment was seen with K+–sparing diuretic or β1–selective blockade. Substitution or addition of amiloride may be the solution to preventing thiazide–induced diabetes mellitus.

  • Two double–blind, placebo–controlled, crossover studies were performed.
  • In study 1 (41 patients), the authors found that changes in glucose during a 2–hour oral glucose tolerance test could be detected after 4 weeks of treatment with bendroflumethiazide.
  • In study 2, 37 patients with essential hypertension received, in random order, 4 weeks of once–daily treatment with hydrochlorothiazide (HCTZ) 25 to 50 mg, nebivolol 5 to 10 mg, combination (HCTZ 25–50 mg+nebivolol 5–10 mg), amiloride (10–20 mg), and placebo.
  • Each drug was force titrated at 2 weeks and separated by a 4–week placebo washout.
  • At each visit, the authors recorded blood pressure and performed a 75–g oral glucose tolerance test.
  • Primary outcome was the difference in glucose (over the 2 hours of the oral glucose tolerance test) between 0 and 4 weeks, when HCTZ and amiloride were compared by repeated–measures analysis.

  • For similar blood pressure reductions, there were opposite changes in glucose between the 2 diuretics (P<0.0001).
  • Nebivolol did not impair glucose tolerance, either alone or in combination.
  • There was a negative correlation between Δpotassium and Δ2–hour glucose (r=–0.28; P<0.0001).
  • In 2 crossover studies, 4 weeks of treatment with a thiazide diuretic impaired glucose tolerance.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access Full Text, PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Ophthalmology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Ophthalmology Articles

1 Fingernail-induced corneal abrasions: case series from an Ophthalmology Emergency Department Cornea, June 26, 2014    Clinical Article

2 Prevention of posterior capsule opacification by an intracapsular open capsule device Investigative Ophthalmology & Visual Science, June 6, 2014    Clinical Article

3 The Handy Eye Check: a mobile medical application to test visual acuity in children Journal of AAPOS, June 20, 2014    Clinical Article

4 Vimentin knockdown decreases corneal opacity Investigative Ophthalmology & Visual Science, June 10, 2014    Clinical Article

5 A new slit lamp–based technique for anterior chamber angle estimation Optometry and Vision Science, June 13, 2014    Clinical Article

6 Daytime and night time effects of brimonidine on IOP and aqueous humor dynamics in participants with ocular hypertension Journal of Glaucoma, June 18, 2014    Clinical Article

7 A preliminary study of the neuroprotective role of citicoline eye drops in glaucomatous optic neuropathy Full Text Indian Journal of Ophthalmology, June 23, 2014    Free full text    Clinical Article

8 Comparison of 1-year therapeutic effect of ranibizumab and bevacizumab for myopic choroidal neovascularization: a retrospective, multicenter, comparative study Full Text BMC Ophthalmology, June 4, 2014    Free full text    Clinical Article

9 Intrinsic and extrinsic risk factors for sagging eyelids JAMA Dermatology, June 4, 2014    Clinical Article

10 The accuracy of Goldmann applanation tonometry over silicone hydrogel contact lenses in patients with glaucoma Contact Lens and Anterior Eye, June 5, 2014    Clinical Article

11 Visual loss and optic nerve head swelling in thiamine deficiency without prolonged dietary deficiency Full Text Clinical Ophthalmology, June 13, 2014    Free full text

12 Phacoemulsification versus peripheral iridotomy in the management of chronic primary angle closure: long-term follow-up International Ophthalmology, May 5, 2014    Clinical Article

13 Quantification of metamorphopsia in chronic central serous chorioretinopathy after half-dose verteporfin photodynamic therapy Retina, June 5, 2014    Clinical Article

14 An update on the surgical management of pterygium and the role of loteprednol etabonate ointment Full Text Clinical Ophthalmology, June 25, 2014    Free full text    Review Article

15 Topical antibiotics for the management of bacterial keratitis: An evidence-based review of high quality randomised controlled trials British Journal of Ophthalmology, May 28, 2014    Evidence Based Medicine    Review Article

16 Fibers found in the eye during and after phacoemulsification cataract surgery Eye, June 5, 2014    Clinical Article

17 Three-year, randomized, Sham-Controlled Trial of dexamethasone intravitreal implant in patients with diabetic macular edema Ophthalmology, June 11, 2014    Clinical Article

18 No cases of endophthalmitis after 20,293 intravitreal injections in an operating room setting Retina, June 5, 2014    Clinical Article

19 Comparison of intravitreal ranibizumab in phakic and pseudophakic neovascular age-related macular degeneration patients with good baseline visual acuity Retina, June 3, 2014    Clinical Article

20 Acute retinal pigment epithelium detachments after photocoagulation Retina, June 5, 2014    Clinical Article

Indexed Journals in Ophthalmology: American Journal of Ophthalmology, Retina, Eye, Corneamore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More