Choice of initial antihypertensive drugs and persistence of drug use-a 4-year follow-up of 78,453 incident users
European Journal of Clinical Pharmacology,  Clinical Article

Selmer R et al. – Thiazides (TZs) and angiotensin II–receptor blockers (ARBs) were the most widely used first–line antihypertensives. Among the men enrolled in the study, ARB users had a somewhat better persistence with antihypertensive treatment than TZ users. Among both genders, continuation on ARBs was more common than continuation on TZs.

Methods
  • All initial users of antihypertensive drugs in 2005 and 2009 registered in the Norwegian Prescription Database were included.
  • Treatment on five index dates at 1–year intervals was recorded.
  • A patient was considered to be under treatment on an index date if a drug had been dispensed within the previous 180 days and to have maintained treatment persistence if he/she was on any antihypertensive treatment on the index date and all previous index dates.

Results
  • Among 78,453 new users of antihypertensives in 2005, women started more often with TZs than men (30 vs. 25 %) and less often with ARBs (22 vs. 25 %).
  • In men, the hazard of non–persistence with antihypertensive treatment was significantly lower among initial ARB users than among TZ users (hazard ratio 0.87, 95 % confidence interval 0.81–0.94); in women no significant difference was found.
  • After 4 years, 49 % of the men and 51 % of the women who had started with plain TZs were still using TZs, whereas 65 % of the male ARB users and 60 % of the female ARB users were still using ARBs.

Please login or register to follow this author.
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Ophthalmology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Ophthalmology Articles

1 Mini-monovision versus multifocal intraocular lens implantation Journal of Cataract & Refractive Surgery, October 8, 2014    Clinical Article

2 Subjective complaints after cataract surgery: Common causes and management strategies Current Opinion in Ophthalmology, December 10, 2014    Clinical Article

3 Original and generic latanoprost for the treatment of glaucoma and ocular hypertension: are they really the same? Clinical and Experimental Pharmacology and Physiology, October 29, 2014    Clinical Article

4 Efficacy of selective laser trabeculoplasty in primary angle-closure glaucoma: a randomized clinical trial JAMA Ophthalmology, December 16, 2014    Evidence Based Medicine    Clinical Article

5 Femtosecond laser-assisted cataract surgery versus standard phacoemulsification cataract surgery: Outcomes and safety in more than 4000 cases at a single center Journal of Cataract & Refractive Surgery, November 17, 2014    Clinical Article

6 Can eating blueberries really help you see better in the dark? American Chemical Society News, December 1, 2014

7 Laser-assisted mini-capsulotomy: A new technique for intumescent white cataracts Journal of Refractive Surgery, December 1, 2014    Clinical Article

8 Ocular toxoplasmosis in the United States: Recent and remote infections Clinical Infectious Diseases, December 24, 2014    Clinical Article

9 What we know about ocular manifestations of Ebola Full Text Clinical Ophthalmology, November 26, 2014    Free full text    Clinical Article

10 Risk factors for developing thyroid-associated ophthalmopathy among individuals with graves disease JAMA Ophthalmology, December 18, 2014    Evidence Based Medicine    Clinical Article

11 Association between aspirin use and age-related macular degeneration: A meta-analysis Investigative Ophthalmology & Visual Science, February 11, 2014    Evidence Based Medicine    Clinical Article

12 Top-selling eye vitamins found not to match scientific evidence American Academy of Ophthalmology News, December 10, 2014

13 Randomized trial of brinzolamide/brimonidine versus brinzolamide plus brimonidine for open-angle glaucoma or ocular hypertension Advances in Therapy, December 4, 2014    Clinical Article

14 Late-day intraocular pressure-lowering efficacy and tolerability of travoprost 0.004% versus bimatoprost 0.01% in patients with open-angle glaucoma or ocular hypertension: A randomized trial Full Text BMC Ophthalmology, December 3, 2014    Free full text    Clinical Article

15 Is aspirin use associated with age-related macular degeneration? A meta-analysis Journal of Clinical Pharmacy and Therapeutics, December 8, 2014    Evidence Based Medicine    Review Article

16 Comparison of ketorolac 0.4% and nepafenac 0.1% for the prevention of cystoid macular oedema after phacoemulsification: Prospective placebo-controlled randomised study British Journal of Ophthalmology, November 25, 2014    Clinical Article

17 Whole-population vision screening in children aged 4-5 years to detect amblyopia The Lancet, December 15, 2014    Review Article    Clinical Article

18 Old drugs offer new treatment hope for leading cause of blindness Cardiff University News, December 1, 2014

19 Physical activity and the 15-year incidence of age-related macular degeneration Investigative Ophthalmology & Visual Science, December 2, 2014    Clinical Article

20 Comparison of outcomes of primary anterior chamber versus secondary scleral-fixated intraocular lens implantation in complicated cataract surgeries American Journal of Ophthalmology, November 7, 2014    Clinical Article

Indexed Journals in Ophthalmology: American Journal of Ophthalmology, Retina, Eye, Corneamore

Looking for a physician job? Let us help!

Register now for our free job placement service.
A career consultant will contact you soon.
Click Here for more information.

Get Started Now!

Free-of-charge, no obligation.

Terms and Conditions For M3 Career Consult

By registering with the M3 Career Consult service you authorize M3 USA Corporation to represent you in your job search. The following is a summary of the terms of our service and our mutual obligations to help you find a job:

  • You designate M3 to act as your agent and represent you in your job search;
  • You will not pay us for this service
  • You will advise us of any companies or positions to which you apply or have applied;
  • You will advise us if you believe you are not capable of performing a position for which we submit you, or for which you interview;
  • You will keep all information we provide you about companies or positions strictly confidential;
  • You will promptly provide us with information we request of you;
  • You will make yourself reasonably available for phone, video and in-person conversations and interviews;
  • You will be truthful in all of your communications with us; and
  • You will advise us if anything above changes.
 

The Top Read Articles of 2014 are Now Available

Scouring thousands of peer-reviewed journals and popular press, Our Editors just released the Top Read Articles of the Year. See the Top Read List