Prognosti Implications of Pigment Epithelial Detachment in Bevacizumab (Avastin)-Treated Eyes With Age-Related Macular Degeneration and Choroidal Neovascularization
Freeman WR et al. – Despite monthly intravitreal bevacizumab injections for neovascular age–related macular degeneration (AMD) patients with a large component pigment epithelial detachment (PED), the majority had minimal to no response of the PED. Sub– and intraretinal fluid response was faster in neovascular AMD without large PEDs, but after 7 months, vision change and reabsorption of intra– and subretinal fluid were similar in the two groups. Sub– and intraretinal fluid response did not appear to be related to PED size. Bevacizumab was very effective in reducing more of the sub– and intraretinal fluid than the PED fluid in AMD with CNV.