The Effects of a Fixed Combination of 0.5% Timolol and 1% Dorzolamide on Optic Nerve Head Blood Circulation

Journal of Ocular Pharmacology and Therapeutics, 05/31/2012

The current results suggest that FCTD1% caused a significant increase in ocular blood circulation on the optic nerve head in healthy Japanese subjects, presumably by a synergistic effect of 0.5% timolol maleate (TM) and 1% dorzolamide hydrochloride (DZ), although neither 0.5% TM nor 1% DZ on their own had a significant effect.

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