Bone-Derived IGF Mediates Crosstalk between Bone and Breast Cancer Cells in Bony Metastases
Cancer Research, 08/17/2012
Hiraga T et al. – The findings suggest that bone–derived insulin–like growth factor (IGF)–I bridges the crosstalk between bone and metastasized cancer cells via activation of the IGF–IR/Akt/NF–κB pathway. Disruption of this pathway therefore may represent a promising therapeutic intervention for bone metastasis.