Granuloma annulare-like eruption associated with B-cell chronic lymphocytic leukemia
Journal of Cutaneous Pathology, 07/27/2012
Sokumbi O et al. – Co–existence of a granuloma annulare (GA)––like infiltrate and cutaneous B–CLL raises the possibility that granulomatous inflammation occurs as a secondary response to dermal infiltration by leukemic cells. Because histopathologic findings can be subtle, knowledge of this association is essential to avoid overlooking the diagnosis. Regardless of whether histopathology reflects a reactive or primary phenomenon, documentation of cutaneous involvement by B–CLL may serve as a rationale for specific treatment of the underlying B–CLL in patients with skin lesions unresponsive to dermatologic therapy and for whom there is no other justification for leukemia–targeted therapy.