Searching for early breast cancer biomarkers by serum protein profiling of pre-diagnostic serum; A nested case-control study Full Text
BMC Cancer,  Clinical Article

Opstal-van Winden AWJ et al. – The authors show that serum protein profiles are already altered up to three years before breast cancer detection.

Methods

  • Nested case-control design we compared 68 women diagnosed with breast cancer within 3 years after enrollment, with 68 matched controls for differences in serum protein profiles
  • All samples were analyzed with SELDI-TOF MS (surface enhanced laser desorption/ionization time-of-flight mass spectrometry)
  • Subset of 20 case-control pairs
  • Serum proteome identified and relatively quantified using isobaric Tags for Relative and Absolute Quantification (iTRAQ) and online two-dimensional nano-liquid chromatography coupled with tandem MS (2D-nanoLC-MS/MS)

Results

  • 2 SELDI-TOF MS peaks with m/z 3323 and 8939, which probably represent doubly charged apolipoprotein C-I and C3a des-arginine anaphylatoxin (C3adesArg), higher in pre-diagnostic breast cancer serum (p=0.02 and p=0.06)
  • With 2D-nanoLC-MS/MS, afamin, apolipoprotein E and isoform 1 of inter-alpha trypsin inhibitor heavy chain H4 (ITIH4) found to be higher in pre-diagnostic breast cancer (p<0.05), while alpha-2-macroglobulin and ceruloplasmin were lower (p<0.05)
  • C3adesArg and ITIH4 have previously been related to presence of symptomatic and/or mammographically detectable breast cancer

Please login or register to follow this author.
► Click here to access Full Text, PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Oncology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Oncology Articles

1 Peanut component linked to cancer spread University of Liverpool News, December 23, 2014

2 Study: How red wine prevents cancer University of Colorado Health News, December 5, 2014

3 Efficacy and safety of radium-223 dichloride in patients with castration-resistant prostate cancer and symptomatic bone metastases, with or without previous docetaxel use: A prespecified subgroup analysis from the randomised, double-blind, phase 3 ALSYMPCA trial The Lancet Oncology, October 24, 2014    Clinical Article

4 'Flying carpet' technique delivers one-two punch of anticancer drugs UNC Health Care System, January 15, 2015

5 New hope to prevent chemotherapy side effects The University of Adelaide News, January 13, 2015

6 Tamoxifen for prevention of breast cancer: extended long-term follow-up of the IBIS-I breast cancer prevention trial The Lancet Oncology, December 24, 2014    Clinical Article

7 Cancer treatment potential discovered in gene repair mechanism Case Western Reserve University School of Medicine News, January 6, 2015

8 Intraoperative radiotherapy versus external radiotherapy for early breast cancer (ELIOT): a randomised controlled equivalence trial The Lancet Oncology, January 24, 2014    Clinical Article

9 Panitumumab plus radiotherapy versus chemoradiotherapy in patients with unresected, locally advanced squamous-cell carcinoma of the head and neck (CONCERT-2): A randomised, controlled, open-label phase 2 trial The Lancet Oncology, January 27, 2015    Clinical Article

10 Popular new year's resolution may decrease cancer risk University of Colorado Health News, January 7, 2015

11 Impact of the U.S. preventive services task force recommendations against PSA screening on prostate biopsy and cancer detection rates The Journal of Urology, December 10, 2014    Clinical Article

12 Epidermal growth factor receptor tyrosine kinase inhibitors vs conventional chemotherapy in non-small cell lung cancer harboring wild-type epidermal growth factor receptor: A meta-analysis Full Text JAMA, April 11, 2014    Free full text    Evidence Based Medicine    Clinical Article

13 Optimal duration of low molecular weight heparin for the treatment of cancer-related deep vein thrombosis: The Cancer-DACUS Study Journal of Clinical Oncology, October 10, 2014    Clinical Article

14 Toughest breast cancer may have met its match Johns Hopkins Medicine, December 11, 2014

15 Hodgkin transformation of chronic lymphocytic leukemia: Incidence, outcomes and comparison to de novo hodgkin lymphoma American Journal of Hematology, January 19, 2015    Clinical Article

16 The dirty side of soap UC San Diego Health System, November 20, 2014

17 Coffee intake and gastric cancer risk Cancer Epidemiology, Biomarkers & Prevention, March 20, 2014    Clinical Article

18 Omission of dacarbazine or bleomycin, or both, from the ABVD regimen in treatment of early-stage favourable Hodgkin's lymphoma (GHSG HD13): an open-label, randomised, non-inferiority trial The Lancet, January 7, 2015    Evidence Based Medicine    Clinical Article

19 Neutrophil to lymphocyte ratio as a prognostic biomarker for men with metastatic castration-resistant prostate cancer receiving first-line chemotherapy: Data from two randomized phase III trials Annals of Oncology, December 18, 2014    Clinical Article

20 Effect of 3 to 5 years of scheduled CEA and CT follow-up to detect recurrence of colorectal cancer: The FACS randomized clinical trial Full Text JAMA, January 16, 2014    Free full text    Evidence Based Medicine    Clinical Article

Indexed Journals in Oncology: Journal of Clinical Oncology, Cancer Research, Annals Oncologymore

 

The Top Read Articles of 2014 are Now Available

Scouring thousands of peer-reviewed journals and popular press, Our Editors just released the Top Read Articles of the Year. See the Top Read List