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Contralateral prophylactic mastectomy in breast cancer patients who test negative for BRCA mutations
The American Journal of Surgery, 09/09/2011
Howard–McNatt M et al. – Increased rates of contralateral prophylactic mastectomy (CPM) have been observed. In authors' study married women were more likely to choose CPM. They recommend genetic genotyping before surgery. These findings warrant further investigation.
Methods- A total of 110 women with breast cancer received genetic testing before surgical treatment.
- Patient demographics, tumor characteristics, surgical treatment, and magnetic resonance imaging use were recorded.
- Results revealed BRCA1/2 mutation in 33%, variant of unknown significance in 6%, and no mutation in 61% of women.
- In BRCA-negative women, 37% chose CPM. Marital status was significant for CPM (P = .03).
- Race, age, stage of presentation, and biomarker status were not associated with choice of CPM.
- Ninety-six percent of CPM recipients underwent breast reconstruction.
- Magnetic resonance imaging use did not affect CPM rates (P = .99).
