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Insulin resistance, central obesity, and risk of colorectal adenomas Full Text
Cancer, 09/02/2011
Ortiz AP et al. –The results support central obesity and insulin resistance, particularly in men, as important risk factors for the development of early colorectal neoplasia.
Methods- The authors collected lifestyle information and fasting blood samples from 1222 participants (320 incident adenoma cases and 902 without adenomas) before their screening colonoscopies.
- Unconditional logistic regression models were used to assess risk associations.
- In multivariate analysis of participants (n=1093) reporting no antidiabetic medication use, those in the top quartile of WHR were twice as likely (odds ratio [OR], 2.18; 95% confidence interval [CI], 1.33-3.57; P-trend=.003) and those in the top quartile of HOMA-IR were 63% more likely (OR, 1.63; 95% CI, 1.09-2.44; P-trend=.01) to have adenomas compared with those in the bottom quartiles.
- Stratified analysis revealed a statistically significant interaction between HOMA-IR and sex (P-interaction=.04), with the association largely limited to men; compared with those in the bottom tertile, men in the top tertile of HOMA-IR were twice more likely to have adenomas (OR, 2.11; 95% CI, 1.18-3.78; P-trend=.01).
