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Molecular mechanisms of liver metastasis
International Journal of Clinical Oncology, 08/26/2011
Kawada K et al. – Recent studies have provided increasing evidence that the chemokine–chemokine receptor system is a potential mechanism of tumor metastasis via multiple complementary actions: (a) by promoting cancer cell migration, invasion, survival and angiogenesis; and (b) by recruiting distal stromal cells (i.e., myeloid bone marrow–derived cells) to indirectly facilitate tumor invasion and metastasis.