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Estrogen levels in nipple aspirate fluid and serum during a randomized soy trial
Cancer Epidemiology, Biomarkers & Prevention, 08/19/2011
Maskarinec G et al. – Soy foods in amounts consumed by Asians did not significantly modify estrogen levels in NAF and serum.
Methods- Crossover design, randomized 96 women who produced 10 μL or more NAF to a high- or low-soy diet for 6 months
- During high-soy diet, participants consumed 2 soy servings of soy milk, tofu, or soy nuts (50 mg of isoflavones per day); during low-soy diet, they maintained their usual diet Estradiol (E2) and estrone sulfate (E1S) were assessed in NAF and estrone (E1) in serum only, using highly sensitive radioimmunoassays
- 6 NAF samples were obtained using FirstCyte aspirator
- Mixed-effects regression models accounting for repeated measures and left-censoring limits were applied
- Mean E2 and E1S were lower during high-soy than low-soy diet (113 vs. 313 pg/mL and 46 vs. 68 ng/mL, respectively) without reaching significance (P = 0.07); the interaction between group and diet was not significant
- No effect of soy treatment on serum levels of E2 (P = 0.76), E1 (P = 0.86), or E1S (P = 0.56)
- Within individuals, NAF and serum levels of E2 (rs = 0.37; P < 0.001) but not of E1S (rs = 0.004; P = 0.97) were correlated
- E2 and E1S in NAF and serum were strongly associated (rs = 0.78 and rs = 0.48; P < 0.001)
