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Outcome of long term active surveillance for estrogen receptor-positive ductal carcinoma in situ
The Breast, 08/17/2011
Clinical Article
Meyerson AF et al. – Long-term active surveillance for DCIS is feasible in a well-informed patient population, but is associated with risk of invasive cancer at surgical excision.
Methods- Retrospective review of 14 women, 12 of whom were enrolled in an IRB-approved single-arm study of 3 months of neoadjuvant endocrine therapy prior to definitive surgical management
- Patients in this report withdrew from parent study opting instead for active surveillance with endocrine treatment and imaging
- 8 women had surgery at median follow up of 28.3 months (range 10.1–70 months)
- 5 had stage I IDC at surgical excision, and 3 had DCIS alone
- 6 women remain on surveillance without evidence of invasive disease for median of 31.8 months (range 11.8–80.8 months)