Elevated serum free light chains are associated with inferior event free and overall survival in hodgkin lymphoma
American Journal of Hematology, 08/17/2011
Thompson CA et al. – The serum free light chain (FLC) assay quantitates free immunoglobulin kappa and lambda light chains, which has prognostic value in plasma cell dyscrasias. However, there is limited data on serum FLC in lymphoid malignancies. The authors analyzed the association of pre–treatment FLC with event–free survival (EFS) and overall survival (OS) in patients with Hodgkin lymphoma (HL). Elevated polyclonal FLC were present in 30% of patients; these patients had an inferior EFS and OS compared to patients with normal FLC.







