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Deregulated microRNAs in multiple myeloma
Cancer, 08/17/2011
Benetatos L et al. – The small molecules interact with important factors such as p53, SOCS1, IGF–1, IGF–1R, vascular endothelial growth factor, NF–kappa B, and others. As such, microRNAs represent an attractive therapeutic target in the context of multiple myeloma interfering with the myeloma regulatory networks. Further studies are needed to better understand their role in myelomagenesis and their therapeutic potential.