Dietary calcium and magnesium intake in relation to cancer incidence and mortality in a German prospective cohort (EPIC-Heidelberg)
Cancer Causes and Control, 07/08/2011
Clinical Article
Li K et al. – This prospective cohort study provides no strong evidence to support that high dietary calcium and magnesium intake in the intake range observed in a German population may reduce cancer incidence or mortality.
Methods- Data of 24,323 participants of the Heidelberg cohort of European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg)
- Participants aged 35–64 years and cancer-free at recruitment (1994–1998)
- Analyzed using multivariate Cox regression models
- Average follow-up time of 11 years
- 2,050 incident cancers diagnosed and 513 cancer deaths occurred
- Dietary calcium intake inversely but not statistically significantly associated with colorectal cancer risk (HR for per 100 mg increase in intake: 0.95; 95% CI: 0.88, 1.02) and lung cancer risk (HR for per 100 mg increase in intake: 0.94; 95% CI: 0.87, 1.02)
- No statistically significant associations observed between dietary calcium intake and site-specific or overall cancer incidence or mortality
- Dietary magnesium intake not statistically significantly associated with any of investigated outcomes
