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Fenretinide-dependent upregulation of death receptors through ASK1 and p38-alpha enhances death receptor ligand-induced cell death in Ewing's sarcoma family of tumours
British Journal of Cancer, 10/14/2010
White DE et al. – Sustained p38MAPK phosphorylation upregulates p75 neurotrophin (p75NTR) and induces apoptosis in Ewing's sarcoma family of tumours (ESFT). As fenretinide induces ESFT death through sustained p38MAPK phosphorylation, authors hypothesised that this may be effected through upregulation of death receptors (DRs) and that treatment of fenretinide plus DR ligands may enhance apoptosis. The synergistic death observed with fenretinide and DR ligands suggests that this combination may be an attractive strategy for the treatment of ESFT.