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B and T Lymphocyte Attenuator Mediates Inhibition of Tumor-Reactive CD8+ T Cells in Patients After Allogeneic Stem Cell Transplantation
The Journal of Immunology, 06/22/2012
Hobo W et al. – The results demonstrate that B and T lymphocyte attenuator (BTLA)–herpes virus entry mediator (HVEM) interactions impair minor histocompatibility antigens (MiHA)–specific T cell functionality, providing a rationale for interfering with BTLA signaling in post–stem cell transplantation therapies.
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