Duplication of CXC chemokine genes on chromosome 4q13 in a melanoma-prone family
Pigment Cell & Melanoma Research, 04/16/2012
Yang XR et al. – The authors confirmed the duplication using quantitative PCR and a custom–made CGH array design spanning the 4q13 region. The duplicated region contains 10 genes, most of which encode CXC chemokines. Among them, CXCL1 (melanoma growth–stimulating activity α) and IL8 (interleukin 8) have been shown to stimulate melanoma growth in vitro and in vivo. The data suggest that the alteration of CXC chemokine genes may confer susceptibility to melanoma.