Breast and cervical cancer in 187 countries between 1980 and 2010: A systematic analysis
The Lancet,

Forouzanfar MH et al. – Breast and cervical cancer are important causes of mortality in women aged ≥15 years. We undertook annual age-specific assessments of breast and cervical cancer in 187 countries.

Methods

  • Systematically collected cancer registry data on mortality and incidence, vital registration, and verbal autopsy data for the period 1980—2010
  • Modelled the mortality-to-incidence (MI) ratio using a hierarchical model
  • Vital registration and verbal autopsy were supplemented with incidence multiplied by the MI ratio to yield a comprehensive database of mortality rates
  • Used Gaussian process regression to develop estimates of mortality with uncertainty by age, sex, country, and year
  • Used out-of-sample predictive validity to select the final model
  • Estimates of incidence with uncertainty were also generated with mortality and MI ratios

Results
  • Global breast cancer incidence increased from 641 000 (95% uncertainty intervals 610 000—750 000) cases in 1980 to 1 643 000 (1 421 000—1 782 000) cases in 2010, an annual rate of increase of 3·1%
  • Global cervical cancer incidence increased from 378 000 (256 000—489 000) cases per year in 1980 to 454 000 (318 000—620 000) cases per year in 2010—a 0·6% annual rate of increase
  • Breast cancer killed 425 000 (359 000—453 000) women in 2010, of whom 68 000 (62 000—74 000) were aged 15—49 years in developing countries
  • Cervical cancer death rates have been decreasing but the disease still killed 200 000 (139 000—276 000) women in 2010, of whom 46 000 (33 000—64 000) were aged 15—49 years in developing countries
  • Recorded pronounced variation in trend in breast cancer mortality across regions and countries

Please login or register to follow this author.
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Oncology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Oncology Articles

1 Germline mutation in BRCA1 or BRCA2 and ten-year survival for women diagnosed with epithelial ovarian cancer Clinical Cancer Research, December 3, 2014    Clinical Article

2 Carboplatin and pegylated liposomal doxorubicin versus carboplatin and paclitaxel in very platinum-sensitive ovarian cancer patients: Results from a subset analysis of the CALYPSO phase III trial European Journal of Cancer, December 19, 2014    Clinical Article

3 Value of 18F-FDG PET/CT and MRI in diagnosing primary endometrial small cell carcinoma Full Text Chinese Journal of Cancer Research, November 24, 2014    Free full text    Clinical Article

4 Comparing robotic surgery with laparoscopy and laparotomy for endometrial cancer management: A cohort study International Journal of Surgery, December 5, 2014    Clinical Article

5 Olaparib combined with chemotherapy for recurrent platinum-sensitive ovarian cancer: A randomised phase 2 trial The Lancet Oncology, December 4, 2014    Clinical Article

6 Prognosis and conditional disease-free survival among patients with ovarian cancer Journal of Clinical Oncology, December 3, 2014    Clinical Article

7 Differential platelet levels affect response to taxane-based therapy in ovarian cancer Clinical Cancer Research, December 15, 2014    Clinical Article

8 Pharmacokinetics of concomitant cisplatin and paclitaxel administered by hyperthermic intraperitoneal chemotherapy to patients with peritoneal carcinomatosis from epithelial ovarian cancer British Journal of Cancer, December 19, 2014    Clinical Article

9 Complications and long-term follow-up on colorectal resections in the treatment of deep infiltrating endometriosis extending to bowel wall Acta Obstetricia et Gynecologica Scandinavica, October 6, 2014    Review Article

10 Checkpoint inhibitors in immunotherapy of ovarian cancer Tumor Biology, December 5, 2014    Clinical Article

11 MEK1 is associated with carboplatin resistance and is a prognostic biomarker in epithelial ovarian cancer Full Text BMC Cancer, December 5, 2014    Free full text    Clinical Article

12 Adenocarcinoma of the uterine cervix: why is it different? Current Oncology Reports, November 11, 2014    Review Article

13 A nationwide population-based retrospective cohort study of the risk of uterine, ovarian and breast cancer in women with polycystic ovary syndrome Full Text The Oncologist, December 9, 2014    Free full text    Clinical Article

14 Effects of BRCA1- and BRCA2-related mutations on ovarian and breast cancer survival: A meta-analysis Clinical Cancer Research, November 17, 2014    Evidence Based Medicine

15 Contraceptive methods and ovarian cancer risk among Chinese women: A report from the Shanghai women's health study International Journal of Cancer, December 30, 2014    Clinical Article

16 Diagnostic role of circulating YKL-40 in endometrial carcinoma patients: A meta-analysis of seven related studies Medical Oncology, December 9, 2014    Evidence Based Medicine

17 Alterations of choline phospholipid metabolism in endometrial cancer are caused by choline kinase alpha overexpression and a hyperactivated deacylation pathway Cancer Research, December 9, 2014    Clinical Article

18 Severe gastrointestinal complications in the era of image-guided high-dose-rate intracavitary brachytherapy for cervical cancer Clinical Therapeutics, December 2, 2014    Clinical Article

19 Hysterectomy-corrected incidence rates of cervical and uterine cancers in Massachusetts, 1995 to 2010 Annals of Epidemiology , November 17, 2014    Clinical Article

20 Platinum sensitivity and CD133 expression as risk and prognostic predictors of central nervous system metastases in patients with epithelial ovarian cancer Full Text BMC Cancer, December 2, 2014    Free full text    Clinical Article

Indexed Journals in Oncology: Journal of Clinical Oncology, Cancer Research, Annals Oncologymore

 

The Top Read Articles of 2014 are Now Available

Scouring thousands of peer-reviewed journals and popular press, Our Editors just released the Top Read Articles of the Year. See the Top Read List