Coffee consumption and risk of cancers: A meta-analysis of cohort studies Full Text
BMC Cancer, 03/17/2011
Yu X et al. – Findings from this meta-analysis suggest that coffee consumption may reduce the total cancer incidence and it also has an inverse association with some type of cancers
Methods- Searched MEDLINE, EMBASE, Science Citation Index Expanded and bibliographies of retrieved articles
- Prospective cohort studies included if they reported relative risks (RRs) and corresponding 95% CIs of various cancers with respect to frequency of coffee intake
- Random-effects meta-analyses and meta-regressions of study-specific incremental estimates to determine risk of cancer associated with 1 cup/day increment of coffee consumption
- 59 studies, consisting of 40 independent cohorts, met the inclusion criteria
- Compared with individuals who did not or seldom drink coffee per day, pooled RR of cancer 0.87 (95% CI, 0.82-0.92) for regular coffee drinkers, 0.89 (0.84-0.93) for low to moderate coffee drinkers, and 0.82 (0.74-0.89) for high drinkers
- Increase in consumption of 1 cup of coffee per day associated with a 3% reduced risk of cancers (RR, 0.97; 95% CI, 0.96-0.98)
- In subgroup analyses coffee drinking associated with reduced risk of bladder, breast, buccal and pharyngeal, colorectal, endometrial, esophageal, hepatocellular, leukemic, pancreatic, and prostate cancers
